Myelodysplastic and Aplastic Anemia
Experimental Adjunct Treatment Protocol Page
Disclaimer: The author of this page is not a medical
professional and makes no drug claims for the following information.
Although the protocol described contains non-toxic, non-prescription
ingredients, and is based on relevant medical research, it also is unproven
by established medical science. The author has no vested or monetary
interest in anything contained on this page, but believes the information
may be able to help those with various anemias and other diseases of the
marrow. It is in this spirit that this is presented to you.
Note: all hyperlinks will open in another browser window. If
you do not close this second window, any hyperlink you click will load into
that same window when it is minimized. To see the information simply
maximize the window.
My interest in
aplastic anemias (and related diseases) began when my father was
sideroblastic anemia in the mid 1990s. He had been exceptionally healthy
for many years until he noticed, at age 69, he was starting to get very
short of breath after only moderate exertion. He thought he must have
developed heart disease and finally went to the Naval Hospital for an
evaluation. The doctors said his heart was fine, but he was very anemic.
Tests determined he had sideroblastic anemia. At first the family breathed a
sigh of relief, but as we learned more about the disease we felt less
assured. We learned it is sometimes referred to as "smoldering leukemia",
and like leukemia is a disease of the bone marrow. It is considered an
"orphan disease" with comparatively little research currently being
undertaken. However it, along with other myelodysplastic and aplastic
anemias, is a disease whose frequency is on the rise. Many researchers think
benzene-related compounds is the culprit, although others disagree.
Even more distressing, we learned that for a person over the
age of 55 or so current medical science offers no treatment options with any
significant likelihood of working. Care consists of regular transfusions of
blood with careful monitoring of blood chemistry, especially iron levels.
For younger patients, myelodysplasia is treated aggressively in a similar
manner to attacking leukemia i.e. killing off the bone marrow with
chemotherapy, followed by a bone marrow transplant.
After learning all of this I became determined to learn more
about this disease in the hope of helping my father.
My Research of the Literature and Scholarly Publications
After many many hours of research I believe that there are
some key nutrients and supplements needed to help fight these anemias and
help ameliorate the damage caused by persistent and profound anemia. Most of
the information to follow will focus on a substance called
N-Acetylcysteine, or NAC for short. This information is written in a
simple writing style so as to not bombard the reader with medical jargon,
and because I am not a doctor nor scientist and do not even begin to claim a
thorough knowledge of the biochemistry involved.
Current research is showing that myelodysplasia and similar
diseases is caused by improper regulation of cellular growth. A substance
called TNF-alpha appears to be main culprit. TNF stands for "tumor necrosis
factor". It does just what the name says. The body uses TNF-alpha to stop
improper cell growth and destroy tumor cells. But in cases of myelodysplasia,
the TNF-alpha for some reason kills off the good, developing bone marrow
cells before they can mature to the point where they then generate red blood
cells and platelets.
This is where N-Acetylcysteine (NAC) comes into the picture.
Way down deep at the cellular level, the body produces and uses substances
called cytokines. These cytokines are basically signalling agents. There are
many different kinds. Depending on what their roles are, cytokines either
make something start or else make it stop. There are cytokines in the body
that tell TNF-alpha to either start killing off cells or stop killing them
off. But in myelodysplasia and related anemias the cytokines do not work
correctly. Instead they turn on the TNF-alpha at the wrong times. See:
Anti-cytokine therapy suggested for myelodysplasic syndromes
Cytokines and TNF-alpha implicated in myelodysplastic syndromes
Elevated TNF-alpha levels noted in patients with myelodysplastic syndromes.
Yet again anti-cytokine therapy suggested
Researchers have found that NAC keeps those cytokines from
incorrectly signalling TNF-alpha to kill off the good but still-developing
bone marrow cells. On top of that, NAC also ensures that TNF-alpha kills
tumor cells when it is needs to. For an analogy, think of those cytokines as
an old fashioned light switch with two push buttons, the TNF-alpha as a
light bulb, and the NAC as someone pushing the buttons on the light switch.
When you want the room dark so you can sleep, you want to be sure the light
is turned off. When you want light so you can read a book before snoozing,
you want the switch to be pushed to the on position. Inside the body, NAC
helps turn on or off these cytokines in an appropriate manner. In the case
of sideroblastic anemia, one important role NAC plays is that of an
anti-cytokine, thus keeping normal bone marrow cells from being killed off
by TNF-alpha. It also helps in the proper signalling of TNF-alpha in
destroying defective bone marrow cells that cannot form viable red blood
cells or hemoglobin. Typically in these anemias normal marrow cells are
eventually crowded out by defective marrow cells to the point where the body
no longer produces blood cells capable of carrying oxygen. See:
NAC prevents inappropriate cell destruction and inhibits damage from low
NAC turns off TNF-alpha when it is incorrectly killing off normal cells
NAC reduces inappropriate signalling of cytokines
NAC regulates cytokines
Again, NAC regulates cytokines
From the above noted research you can see that NAC is being
tested as a therapeutic agent for many ailments, including cancer, leukemia,
and heart disease. However, this in vitro study puts it all together:
NAC reduced TNF-alpha levels. It greatly improved bone marrow cells chance
of surviving. When the normal marrow cells are allowed to mature they then
produce normal red blood cells and platelets.
In summary, I believe strongly that supplementing with N-acetylcysteine
may help myelodysplastic and aplastic anemia patients improve their blood
profile by assisting in the preservation and development of normal bone
marrow cells, and possibly in keeping abnormal cells from reaching maturity.
Suggested Experimental Adjunct Treatment Protocol